Evaluation and management of sepsis in Covid-19 patients

Benrhdier, Hasnaa (a.a. 2019/2020) Evaluation and management of sepsis in Covid-19 patients. Tesi di Laurea in Biologia Sperimentale e Applicata (LM-6), Università degli studi di Sassari, relatore Rubino Salvatore, pp. 36. [Tesi di Laurea magistrale]

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Abstract

Background: Little is known about the incidence of Intensive Care Unit (ICU) and Infectious Diseases Unit (IDU) hospital-acquired bloodstream infections (BSI) in critically ill patients with coronavirus disease 2019 (COVID-19). Materials and methods: We conducted a retrospective observational single-centre study at the Azienda Ospedaliera Universitaria (AOU) in Sassari, Italy including 135 patients with severe COVID-19 admitted to the ICU/IDU between March and December 2020. We evaluated the epidemiological, clinical, and microbiological features, and outcome of ICU/IDU-acquired infections. One hundred and twenty (89%) developed a bacterial or fungal nosocomial infection during ICU/IDU stay. Bloodstream infection occurred after an average of 2 days (median 1 day). There were 193 (45.7%) of Covid-19 blood coltures infection. Catheter-related (38%) bloodstream infections were the most frequent that were produced by a wide spectrum of Gram-positive (25%) and Gram-negative bacteria (17%) and fungi (3%). In 60% of cases, infection was associated with septic shock and a significant increase in SOFA score (data not available). Overall ICU/IDU mortality was 80% (data not available). Bacterial and fungal nosocomial infection is a common complication of ICU and IDU admission in patients with COVID-19. It usually presents as a severe form of infection, and it is associated with a high mortality and longer course of ICU stay. Conclusions: The incidence rate of BSI was moderate, but the cumulative risk of developing BSI increased with ICU/IDU stay. Further study will clarify if the increased risk of BSI we detected in COVID-19 patients treated with anti-inflammatory drugs is outweighed by the benefits of reducing any possible pro-inflammatory dysregulation induced by SARS-CoV-2 (research university working group).

Tipologia di tesi: Tesi di Laurea magistrale
Autore: Benrhdier, Hasnaa
Relatore: Rubino, Salvatore
Correlatore: Castiglia, Nicola; Bazzardi, Riccardo
Disciplina MIUR: Area 06 - Scienze mediche > MED/07 MICROBIOLOGIA E MICROBIOLOGIA CLINICA
Struttura: Dipartimento di Scienze Biomediche
Corsi di Laurea: Biologia Sperimentale e Applicata (LM-6)
Anno Accademico: 2019/2020
Sessione: Estiva
Parole Chiave: Sepsi, AOU Sassari, Covid-19.
Codice ID dell'EPrint: 1390
Data di Deposito: 29 Jul 2021 09:20
Tipo di tesi: Sperimentale
URI: http://unisslaurea.uniss.it/id/eprint/1390

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